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In line with the covalent binding mechanism, in vitro and cell-based thermal-shift assays showed that C1-27 induced a negative shift in the melting temperature indicating protein destabilization on binding (Supplementary Figs 11 and 15)

GSH is the main cellular antioxidant to reduce H 2 O 2 and lipid hydroperoxides (LOOH) catalyzed by GPXs 589,590

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Eso significa problemas para las mitocondrias, que pierden energa y se llenan de desechos celulares