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By enriching our understanding of protein degradation, we can begin to formulate strategies to treat neurodegenerative diseases remediating aspects of UPS dysregulation

Together, these data support a model in which adoptively transferred splenocytes from aged mice initiate a systemic inflammatory cascade, which in turn activates and expands endogenous tissue-resident macrophages, leading to sustained tissue functional impairment

And like all transformations, it comes with fire