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Moreover, nicotine suppresses M1 microglia cell differentiation and decreases TNF- release from these cells, impairs Th1 and th17 cells differentiation which consequently resulted to the protection of neurons [231]

During fetal gametogenesis the molecular instruction book for the development of the following generation is in large part written

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Besides the alterations caused on the differentiated tissues, Tamashiro et al.28 showed that the cigarette smoke has a negative impact on the ciliogenesis process in a dose-dependent fashion to the respiratory epithelium in the maturation and differentiation phases