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Treatment groups received stable gastric pentadecapeptide BPC 157 orally in drinking water at doses of 10 g/kg or 10 ng/kg, beginning five minutes post-surgery

To investigate the neural mechanisms of Cagrilintide, next-generation sequencing (NGS) was performed on three key hypothalamic and brainstem regions: the area postrema/nucleus tractus solitarius (AP/NTS), lateral parabrachial nucleus (LPBN), and ventromedial hypothalamus (VMH)

In particular, the astrocytic ApoE (complexed with cholesterol) promotes synaptogenesis (Mauch et al., 2001), with ApoE accumulating near the synapses (Konings et al., 2021)