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Their relative efficacy depends on absorption, bioavailability, dose, duration, and individual hepatic capacityall factors that vary significantly across populations and genetic backgrounds

aOoC platforms offer a promising route to recreate individual immune environments and support the development of tailored therapies and new immunomodulatory drugs

To verify the functions of these overlapping genes, we conducted KEGG enrichment analysis and found that these genes were significantly enriched in the VEGF signaling pathway, FoxO signaling pathway, MAPK signaling pathway, mTOR signaling pathway, and Wnt signaling pathway (Figure 1B)

Further exploration of the direct targets or receptors of the mitochondria-derived peptide MOTS-c in regulating bone metabolism, upstream and downstream signaling, and other molecular mechanisms is required