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1) Patients with hypersensitivity reaction to thioctic acid (a-lipoic acid) and components of this drug 2) Children and adolescents (less clinical experience) 3

Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG oncology RTOG 1016): a randomised, multicentre, non-inferiority trial

New York, NY, USA: 1980

[2] Cell Line:PHGDH-dependent (MDA-MB-468, BT-20, HCC70, HT1080, MT-3) and PHGDH-independent (MDA-MB-231, ZR-75-1, SK-MEL-2) human cancer cell lines Concentration:Dose-response concentrations Incubation Time:4 days Result:Exhibited EC 50 values of 8-16 M for PHGDH-dependent cell lines