Potential users should be aware that while preclinical safety appears excellent, the absence of extensive human clinical trials means unknown risks may exist
Stierand, K., & Rarey, M
Tremor: can occur at rest, in the hands, limbs, or can be postural Muscular: stiff muscles, difficulty standing, difficulty walking, difficulty with bodily movements, involuntary movements, muscle rigidity, problems with coordination, rhythmic muscle contractions, slow bodily movement, or slow shuffling gait Sleep : early awakening, nightmares, restless sleep, or sleep disturbances Whole body: fatigue, dizziness, poor balance, or restlessness Cognitive: amnesia, confusion in the evening hours, dementia, or difficulty thinking and understandin Speech: difficulty speaking, impaired voice, soft speech, or voice box spasms Nasal: distorted sense of smell or loss of smell Urinary: dribbling of urine or leaking of urine Mood: anxiety or apathy Facial: jaw stiffness or reduced facial expression Also common: blank stare, choreoathetosis, constipation, depression, difficulty swallowing, drooling, falling, fear of falling, loss in contrast sensitivity, micrographia, neck tightness, trembling, or weight loss
doi: 10.1136/annrheumdis-2018-214125
