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Predrag Sikirics group (School of Medicine, University of Zagreb, 1991 ) Most common experimental dose in animal studies: 10 g/kg intraperitoneally or per os, daily Standard targeted pathways: VEGFR2 angiogenesis, NO synthase , 5-HT2A serotonin receptor, dopamine D2 receptor Clinical program in Croatia halted at Phase 2 (Crohns disease) WADA Prohibited List: added in 2022 to category S0 (Non-Approved Substances) Reference sources (PubMed) Sikiric P

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A subsequent analysis suggested that NAC may benefit a subgroup of IPF patients with the TOLLIP rs3750920 TT genotype (Oldham et al., Am J Respir Crit Care Med, 2015) [46]

Metallostasis is tightly orchestrated by upstream sentinels, metallosensors, specialized proteins or RNAs specific for a cognate metal that detects the bioavailability of that metal in the cell, and by doing so, control the expression of genes that encode other players in the metallostasis network (Figure 1)