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23 Functional variants of several of these metabolizing enzymes were linked to altered nicotine metabolism in smokers, 15,16 and individuals with reduced or nonfunctional CYP2A6 activity were shown to be significantly less likely to become smokers, and for those who do become smokers, they consumed fewer cigarettes and scored lower for nicotine dependence

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doi:10.1016/S0899-3289(05)80044-6

New York retained its #1 spot as the most expensive state for smokers, while Massachusetts moved up from #6 to #4, highlighting the increased financial burden smoking places on each state