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Covalent functionalisation forms stable bonds via amidation, esterification, or silylation, ensuring durable conjugation for drugs, proteins, or imaging agents, whereas non-covalent approaches rely on stacking, electrostatic interactions, adsorption, or chelation, ensuring reversible binding, well-suited for stimuli-responsive delivery [33]

Analytical method development : Due to its defined structure and robust bioactivity, Dihexa serves as a reference standard in analytical chemistry applications