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10 In contrast, primary total knee arthroplasty (TKA) had an incidence rate of 429/100,000, 11 and recent projections estimate an 85% increase in TKAs by 2030

Depletion of beneficial taxa such as Odoribacter (Bacteroidetes) and Lachno Clostridium (Firmicutes), along with increased abundance of pro-inflammatory taxa including Ileibacterium and Olsenella , was associated with reduced SCFA gene expression, downregulation of tight junction proteins (occludin and claudin-1), and microglial activation in the amygdala and arcuate nucleus, indicating gut barrier disruption and neuroinflammation that coincided with anxiety-like behavior

KEGG pathway analysis ( b )

MR imaging tracking of inflammation-activatable engineered neutrophils for targeted therapy of surgically treated glioma