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Yet, in a recent trial in patients with chronic obstructive pulmonary disease (COPD), oral administration of sulforaphane for four weeks failed to induce the expression of Nrf2, NQO-1, and HO-1 in alveolar macrophages, bronchial epithelial cells, or peripheral blood mononuclear cells (17)

Second, even taken at face value, an assay-specific potency ratio is not a measure of whole-organism effect: it does not mean Dihexa is millions of times more effective in a living brain, where absorption, distribution, and signaling context all differ