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Sept 20: The FDA surprised ARS Pharmaceuticalsif the tone of the companys press release is any indicationby issuing a Complete Response Letter for neffy, an epinephrine nasal spray, in type 1 allergic reactions, including anaphylaxis

D-Retro-Inverso (DRI) modification addresses this by: using D-amino acids (mirror images of natural L-amino acids) and reversing the sequence

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improved Fer-1s plasma stability by replacing the ethyl ester with a tert-butyl ester and adding an imine, yielding SRS16-86 (EC50 = 350 nM) with enhanced stability but reduced activity due to weaker target binding (Linkermann et al., 2014)