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International Immunopharmacology, 115 , Article 109628

For patients whose primary goal is fat loss and body composition improvement: Ipamorelin may be preferred due to its selective GH stimulation without cortisol elevation Cortisol is directly antagonistic to fat loss, particularly visceral fat The clean GH pulse from ipamorelin supports lipolysis without metabolic interference Sermorelin also supports fat metabolism through sustained GH improvement The best approach depends on individual factors including baseline hormone levels, cortisol status, and treatment goals

However, the precise mechanisms by which QCT ameliorates endothelial dysfunction in PE are not yet fully understood

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