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Furin also regulates the transcription factor NKX2-5, which is essential for both normal heart development and CV function 346

Kurzweil is pointing at something more structural, not a sequential handoff but a merger where the source of an idea cant always be cleanly attributed

4.2 Emphysema Emphysema represents another critical pathological hallmark of COPD, defined as abnormal permanent enlargement of the airspaces distal to the terminal bronchioles, accompanied by destruction of alveolar walls and without significant fibrosis. Clinically, two primary subtypes predominate: centrilobular emphysema and panlobular emphysema

These factors make joint inflammation last longer and delay relief