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When water enters the skin, it hydrates cells as well as the extracellular matrix, which can reduce the appearance of fine lines and wrinkles

Lu G, Wang X, Liu J, Yu K, Gao Y, Liu H, Wang C, Wang W, Wang G, Liu M, Mao G, Li B, Qin J, Xia M, Zhou J, Liu J, Jiang S, Mo H, Cui J, Nagasawa N, Sivasankar S, Albertsen MC, Sakai H, Mazur BJ, Lassner MW, Broglie RM (2014) Application of T-DNA activation tagging to identify glutamate receptor-like genes that enhance drought tolerance in plants

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CRLs are regulated by cycles of activation through modification of the cullin C terminus with NEDD8 (neddylation), followed by deneddylation of substratefree CRLs and substrate receptor exchange (Goldenberg et al , 2004