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Dosing Phases, Titration & Cycling Unlike short recovery peptides, semaglutide is not run in on/off cycles. The documented protocol is a single continuous escalation to a maintenance dose that is then held, because the metabolic effect depends on sustained receptor engagement weight tends to return when the drug is stopped

2.1.4 Ensemble docking and affinity ranking The 50 key conformations were used as input for an ensemble docking procedure, where all compounds belonging to the key clusters 31, 4, 19, 50, 35, 20, 36, 42, and 23 were docked