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Figure 3 It has been reported that Sorafenib inhibits the Xc- system transport of cysteine, leading not only to ferroptosis but also inducing ERS, such as eIF2 phosphorylation, and upregulation of ATF4 and cation transport-regulated homologue 1 ( The activation of the PERK-eIF2-ATF4-CHOP pathway mediated by ERS promotes p53 expression and is involved in the interaction between ferroptosis and apoptosis

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