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Small-molecule inhibitors and monoclonal antibodies have further expanded systemic options by selectively targeting key oncogenic pathways, including epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR), B-Raf proto-oncogene (BRAF) and anaplastic lymphoma kinase (ALK) [3]

E., Collier, C

In cases of severe hepatic impairment, the drugs initial dose might need to be reduced and closely monitored

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