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Oral B12 supplementation is more accessible and cost-effective but relies on gastric intrinsic factor for absorption, rendering it unsuitable for individuals with gastric disorders or malabsorption syndromes

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found that children with sepsis, and particularly those who are administered unbalanced crystalloid solutions during resuscitation, demonstrate a loss or deterioration of the EG, and this effect peaks approximately 6 h after the infusion and is often associated with metabolic acidosis and AKI (134)