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For pediatric patients, we recommend focusing on foundational health strategies such as proper nutrition, gut support, and lifestyle modifications to promote overall well-being

The resulting decline in SCFAs, particularly butyrate, diminishes activation of FFAR2/FFAR3 receptors on enteroendocrine L-cells and lowers GLP-1 secretion

For example, some have found that having the e4 allele did not increase risk among Black people, 90 , 91 , 92 while other studies have found that it significantly increased risk