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However, as the spinal canal progressively narrows, it can impinge on spinal nerve roots or the spinal cord, leading to lower back pain and neurological symptoms

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To this end, BALB/c mice, which are genetically deficient in endogenous melatonin production (28), were intranasally challenged with 25 g Alternaria alternata (AA) or PBS daily for four days, with or without concurrent intraperitoneal melatonin treatment using established protocols described previously (18, 2931) ( Figure 1A )