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In fact, single cell RNA sequencing of transcriptomic differences between quiescent and activated NSCs revealed that gene expression of glycolytic and fatty acid oxidation enzymes is increased during quiescence, switching over to a more oxidative phosphorylation-based transcriptional program upon activation (Shin et al., 2015)

The good news is that studies have also shown that glutathione supplements may help to reverse some of the damage

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