Key Takeaway: The GHK-Cu literature remains largely pre-clinical, with stability handling and sourcing variability as the two operational risk factors most likely to compromise research reproducibility
These provide additional tyrosine residues to be phosphorylated by the tyrosine kinase domain of the activated receptor that will attract further molecules containing SH2 domains or plekstrin homoly (PH) domains, these last will anchor IRS to phosphoinositides on the cell membrane
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10.1016/s0928-4257(97)89474-0 [DOI] [PubMed] [Google Scholar] Sikiric P., Seiwerth S., Grabarevic Z., Rucman R., Petek M., Jagic V., et al