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Efficacy Winner: Musely Spot Cream Muselys Spot Cream has the edge in efficacy due to its availability as five different prescription formulas, three of which include research-supported concentrations of hydroquinone an ingredient that experts consider the standard depigmentation or skin lightening agent.3 On its own, 4% hydroquinone cream improved subjects melasma by 40% in one study (from 2000) and by about 77% in another (from 2003).4 5 Moreover, a more recent 2020 review found that hydroquinone by itself or paired with tretinoin and a corticosteroid are two of the most effective and well-studied treatments for melasma.6 The Spot Cream formula M+ boasts all three aforementioned ingredients, Erase has both hydroquinone and hydrocortisone, and Nurture contains hydroquinone

Marcelis M, Suckling J, Woodruff P, Hofman P, Bullmore E, van Os J (2003)

Morimoto J, Yasuhara T, Kameda M, Umakoshi M, Kin I, Kuwahara K, et al

Pre-formulated GHK-Cu serums retain 8085% peptide activity for 6090 days when stored at 28C in amber glass after opening, compared to 3045 days at room temperature