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But 23% is still a meaningful step up from what semaglutide (Wegovy) achieves on its own, where the average tends to land around 14 to 15%

In particular, LEAP2 (liver-expressed antimicrobial peptide 2), an endogenous antagonist of the ghrelin receptor GHSR, has emerged as a potential target for mitigating the weight regain often observed after discontinuation of GLP-1-based therapies [22,23]

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