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Using genome-wide chromosomal analysis methods, Celestino-Soper and coauthors[43] identified 55 potentially pathogenic copy number variants, among those and in the male samples, a deletion of exon 2 of the TMLHE gene (trimethyllysinehydroxylase epsilon) was found, this gene encodes the first enzyme in the biosynthesis of carnitine which is located in mitochondria

N-acetyl-cysteine (NAC) is included in this formula, as this stable form of cysteine supplies important precursors to the production of glutathione

J Natl Compr Canc Netw 6(9):818-49, 2008

Murayama team finding that the induction of typical CYP450s in ihPS-derived hepatocyte occurred after normal culture could facilitate the use of these cells for drug metabolism (Murayama and Yamazaki, 2018)