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In many cases, this stems from absorption issues that are easy to overlook, such as age-related digestive changes or interactions with certain medications

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However, even a 50% reduction in worm burden would decrease the human health problems caused by schistosomiasis, and a combination of auranofin (or another TGR inhibitor) with an agent that works by a different mechanism might be more effective and would also reduce the chances of the parasite developing drug resistance