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In the epidermis of smokers, we observed a significant upregulation of filaggrin, loricrin, and a trend of increased involucrin but no differences were found in the case of transglutaminase 1 and kallikrein-related peptidase 7, on the gene and protein levels

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These two cigarettes were chosen because 3R4F is the most widely used research cigarette in the literature, whereas 1R6F is newly developed to better reflect products currently on the market

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