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If your powder arrived warm or was left on a hot porch, potency may already be compromised

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doi:10.1016/j.aquatox.2014.11.003 Khaleel NDH, Mahmoud WMM, Olsson O, Kmmerer K (2016) UV-photodegradation of desipramine: impact of concentration, pH and temperature on formation of products including their biodegradability and toxicity

But animal studies extending up to 6 months show no organ toxicity or adverse histological changes (Sikiric et al., Toxicology and Applied Pharmacology, 2019)