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On the one hand, B6 can decrease high homocysteine blood levels that may increase the risk of Alzheimers ( One study in 156 adults with high homocysteine levels and mild cognitive impairment found that taking high doses of B6, B12 and folate (B9) decreased homocysteine and reduced wasting in some regions of the brain that are vulnerable to Alzheimers ( However, its unclear if a decrease in homocysteine translates to improvements in brain function or a slower rate of cognitive impairment
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Check vitamin B12 levels in people treated with metformin who have symptoms suggestive of vitamin B12 deficiency This will also include patients found to have megaloblastic anaemia (raised mean corpuscular volume [MVC]), who may be asymptomatic (MHRA, 2022)
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