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The lack of dose proportionality observed in SL apomorphine exposure appears to be more pronounced in patients with Parkinsons disease compared to healthy subjects, which may be attributed to extrinsic factors, such as SL film contact time under the tongue and dry mouth [27]

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Third, since conditional Slc7a11 knockout mice were unavailable, our in vivo analysis relied on pharmacologic inhibition of the cystine/glutamate transporter and cannot completely exclude off-target effects of sulfasalazine or the contribution of other cell types beyond dendritic cells and fibroblasts in glutathione synthesis

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