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Yip RG-C, Boylan MO, Kieffer TJ, et al

We also found that some differential metabolites like trans-cinnamate and sphingosine 1-phosphate was significantly correlated with IL-13, IP-10, IFN-, and Eotaxin ( Padj 0.05), such as 3-hydroxyphenylacetate and prostaglandin H2, were also significantly correlated with IL-12, MCP-1 and IL-7 among patients with MS ( Padj 0.05) ( Figure S6 )

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Because each peptide acts on a different node of the same shared pathways (the VEGF axis, NF-kB suppression, ECM remodeling), the combination is theoretically additive rather than redundant