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Specifically, it upregulates specific microRNAs (miRNAs) to silence the expression of two critical molecules: miR-155, miR-181b, and miR-361 target Aicda, whereas miR-23b, miR-30a, and miR-125b target Prdm1 (encoding B lymphocyte-induced maturation protein-1, Blimp-1)

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Researchers utilize this mechanism to explore downstream effects on SIRT1 activation, which is a critical regulator of mitochondrial biogenesis, fat oxidation, and glucose metabolism