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99 GenetG.BoyK.MathivetT.OlaR.ZhangF.DubracA.et al (2019)

The 4 mg arm landed near the territory that semaglutide occupies, the 8 mg arm matched what tirzepatide achieves at its top dose, and the 12 mg arm went somewhere no single or dual agonist had reached in a trial of that size

However, modern environments present constant sources of immediate gratification that can hijack these ancient systems, leading to motivational dysfunction that physicians increasingly observe in clinical practice