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Although HF development occurs predominantly during the embryonic life, over- and/or under-activation of signaling pathways, such as sonic hedgehog (shh), notch, TGF-, and Wnt/-catenin, which regulate epithelialmesenchymal interaction in HF, play roles in periodic regeneration of HF and, hence, hair cycling in adult [22]

PMID: 26014291

In these women, pregnancy and gestational age is estimated by ultrasonography (USG)

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