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Our notion was further supported by the fact that with DTNB, a small artificial disulphide substrate 22 , hTrxR1 W114A,U498C showed the same kinetic constants as hTrxR1 U498C , because Trp114 hTrxR1 is not involved in binding of DTNB to the C-terminal active site (Table 2)
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It appears that without correct analysis, observation or consultation with patients many of our doctors truly believe we only need four injections a year because this is what has been repeatedly presented to them
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