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Note that the cytoprotection concept, as originated by Robert [16,17] and Szabo [18,19,20,21], is commonly regarded as a breakthrough in gastroenterology [22,23,24,25,26]

These landmark studies showed that mice with adipose-tissue-specific NNMT knockout remained lean when fed high-fat diets that caused wild-type mice to become obese, and that these protected mice had increased energy expenditure, enhanced fatty acid oxidation, improved glucose tolerance, and elevated NAD+ levels in adipose tissue

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Serious neuropsychiatric and neurological problems can develop, if left untreated