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These conditions include cardiovascular disease, diabetes mellitus, cancer, chronic kidney disease, obesity, cataracts, and metabolic syndrome, as well as disorders that impact brain and bone health (1, 2)

While the hepatotoxic effects of APAP overdose are well documented, the intricate interplay between oxidative stress, cellular damage, and the inflammatory response requires further elucidation

Ethics declarations Ethics approval and consent to participate The study protocol involving human tissues adhered to the Declaration of Helsinki and was approved by the review board of Renmin Hospital of Wuhan University (WDRY2021-KS047)

Nanoparticles also cause changes in protein structure and interact with cell membrane lipids [2, 22, 23]