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In addition, the production of acetic acid, propionic acid and butyric acid was increased in the silybin-treated group, whereas the production of formic acid and the conversion of cytotoxic secondary metabolites were decreased

Therefore, increased ROS/RNS levels induced by several clinical conditions may play a deleterious effect on different biomolecules (e.g., lipids, proteins and nucleic acids), organelles and antioxidant defenses, leading to exacerbate nitro-oxidative stress, mitochondrial dysfunction, glial activation and inflammatory response

Global burden of 87 risk factors in 204 countries and territories, 19902019: a systematic analysis for the Global Burden of Disease study 2019