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In our model the computed value of GSH transport out of the cell (Table 4) is V cGSHb = 1152 and the rates of Cys, Gly, and Glut import are also high (Table 4), although we assume that 10% per hour of the amino acids in the blood are lost to non-liver cells and an additional 25% of Cys is lost by conversion to cystine
Germande O, Ducret T, Quignard JF, Deweirdt J, Freund-Michel V, Errera MH, Cardouat G, Vacher P, Muller B, Berger P, Guibert C, Baudrimont M, Baudrimont I (2022) NiONP-induced oxidative stress and mitochondrial impairment in an in vitro pulmonary vascular cell model mimicking endothelial dysfunction
The Beers Criteria, a guideline for medication use in older adults, lists NSAIDs as potentially inappropriate due to high risk of GI bleeds and renal failure