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Along with the induction of chronic inflammation, cigarette smoke and its active ingredients can directly activate nAChRs, and form DNA adducts to initiate tumorigenesis in the GI tract

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These findings were also documented in similar studies 20,22

Recent data from sources like the National Institute on Drug Abuse (NIDA) shows about 30% of marijuana users may develop cannabis use disorder, which includes strong cravings and withdrawal symptoms like irritability or sleep issues. The American Psychiatric Association notes risks range from 9-30% for dependence among users