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GLS1 is the main isotype expressed in cancer cells and has been shown to be upregulated in a variety of cancers, including breast cancer, lung cancer, cervical cancer, and brain cancer

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Reactive species, both oxygen (ROS) and nitrogen (RNS), have unpaired valence electrons (Ivanov et al

We also included metformin in our SARS-CoV-2 infection experiments revealing that it inhibited infection only at very high concentrations at an IC 50 of 459 M in Calu-3 cells, again without showing any cytotoxicity (Fig