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How Topical GHK-Cu May Work (Mechanisms) 1) Extracellular matrix (ECM) remodeling In vitro, ex vivo, and small clinical contexts, GHK-Cu has been reported to support collagen I/III , elastin , and glycosaminoglycan synthesis and to modulate MMP/TIMP activitypathways central to dermal structure and resilience (PubMed