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Tesamorelin and ipamorelin are growth hormone-releasing peptides with distinct mechanisms of action and clinical evidence bases

To test this, we propose a minimal feasible, biomarker-enriched, single-arm trial for this patient subset, with co-primary endpoints of safety and objective response rate (ORR)

Vitamin injections last anywhere from a few weeks to 1 month

It is also important to distinguish lactylation dependencies between resident microglia and recruited macrophages, and to integrate lactylation with glioma genotype and chromatin background, including IDH status, to identify truly lactylation-addicted tumors