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The orexigenic effect is mediated through GHSR-1a activation of NPY/AgRP neurons in the hypothalamus, with downstream engagement of reward circuits in the ventral tegmental area (Ghrelin signaling in VTA, 2015)

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Given these essential functions, serum copper levels are closely associated with cardiometabolic risk factors, including dyslipidemia, type 2 diabetes, and obesity, and are regarded as predictive indicators of cardiovascular disease risk [29]