Cross-trial scans favor tirzepatide: semaglutide measured about 62:38 fat-to-lean loss versus roughly 75:25 for tirzepatide. The scan overstates muscle loss, however, because lean mass includes water and organs
Gather your supplies Before opening anything, have everything ready on a clean surface
On the other hand, with ligation of the inferior caval vein occlusion we made a recapitulation of Virchow
At minimum: Outcomes Weight trend (weekly average) Waist circumference Body composition if available (DEXA, BIA with consistency) Strength markers (basic lifts, grip strength, functional tests) Safety Blood pressure + resting HR A1c and fasting glucose (more often if diabetes) CMP (liver/kidney) Lipids (periodic) If manipulating GH/IGF-1 signaling: IGF-1 (and clinical context matters) Stop criteria Persistent tachycardia, edema, severe fatigue, worsening glycemia, abnormal labs, or new symptoms you cant explain The what to ask your clinic questions (high signal, low fluff) If a clinic recommends a peptide stack, ask: What is the problem were solving, in one sentence
