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An important note on NSAIDs: while ibuprofen and similar medications help with pain, some research suggests they may slightly impair bone healing

While it appears to have a gentler profile than traditional hypnotics, the long-term effects of exogenous administration, its exact metabolic fate, and potential for interaction with complex neuroendocrine disorders remain unknown outside of controlled research settings

It is less suitable for individuals who are non-verbal or who have significant intellectual disabilities, for whom other emotional regulation approaches (such as sensory-based strategies or visual supports) may be more appropriate