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To further characterize these interactions, we constructed a molecular interaction network (Figure 7C) revealed three functionally interconnected modules: ( Consistent with multi-omics findings, KEGG pathway analysis identified glutathione metabolism as the most significantly perturbed shared pathway (Figure 8A), exhibiting coordinated changes between upregulated antioxidant enzymes such as Gpx3 and Mgst1 alongside depleted glutathione derivatives, supporting redox imbalance as a key pathogenic feature

"Mechanistic studies on a novel, highly potent gold-phosphole inhibitor of human glutathione reductase"

Several risk factors including age, hypertension, ischemic heart disease, diabetes, and chronic respiratory disease (Khanfar and Al Qaroot, 2020) increase the fatality rate (Ruan et al., 2020

Its connection to skin brightening primarily revolves around its ability to affect melanin production