The aspect of BBB protection from this molecule warrants investigation in the context of MS as another pathway in slowing disease progression
Biosci Rep 17:293302, PMID: 9337484 Sato T, Machida T, Takahashi S, Iyama S, Sato Y, Kuribayashi K, Takada K, Oku T, Kawano Y, Okamoto T, Takimoto R, Matsunaga T, Takayama T, Takahashi M, Kato J, Niitsu Y (2004) Fas-mediated apoptosome formation is dependent on reactive oxygen species derived from mitochondrial permeability transition in Jurkat cells
Anti-Doping Agency (USADA). It falls under Category S2: Peptide Hormones, Growth Factors, Related Substances, and Mimetics on the WADA Prohibited List, often specified as a "Growth Hormone Releasing Hormone (GHRH) and its analogues" or a "Growth Hormone Secretagogue (GHS)". The ban is due to its potential to unfairly enhance athletic performance by increasing muscle mass, strength, reducing fat, and improving recovery. The prohibition applies regardless of its mechanism of stimulating endogenous GH, as the outcome of artificially elevated GH/IGF-1 is the concern
The conversion of oxoarsenical species to thioarsenicals (for example, conversion of DMAs V to dimethylthioarsenic) occurs via a reaction with hydrogen sulfide generated in tissues (Naranmandura et al., 2007)
